Tired? Your Spark Plugs May Be Misfiring
WEDNESDAY, Dec. 4 (HealthScoutNews) -- A breakdown in the system that helps the
body respond to stress may play a role in chronic fatigue syndrome, says a study
in the November/December issue of Psychosomatic Medicine journal. The research shows that subtle changes
in a hormonal stress response system called the hypothalamus-pituitary-adrenal (HPA)
axis could be a factor in chronic fatigue syndrome. The HPA axis uses three hormones to help
the body remain stable during physiological and psychological stress. The
hypothalamus secretes a hormone that stimulates the pituitary gland to secrete a
second hormone, which then prompts the adrenal gland to produce cortisol. A problem anywhere along that chain can
result in a variety of diseases, and that may include chronic fatigue syndrome,
the researchers say. People with chronic fatigue syndrome
experience debilitating fatigue and may also have muscle aches, low-grade fever
and sleep disturbances. This study included about 40 people
between the ages of 30 and 50. Half of them suffered from chronic fatigue and
the other half were healthy. All the study participants filled out
questionnaires that measured fatigue, depression and coping skills. The participants were given stress tests
and then had blood, cardiovascular and saliva tests to check on their HPA axis. The study found that people with chronic
fatigue syndrome had significantly lower response levels of one of the HPA
hormones called ACTH before and during the stress tests.
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